AREAS OF SPECIALTY:

• Disabled autophagy as a hallmark of aging

• Gerogenes and gerosuppressor genes

• From geroscience to geromedicine

Guido Kroemer, M.D., Ph.D., PU-PH

Professor at the Faculty of Medicine of the University of Paris Descartes, DIRECTOR OF THE METABOLOMICS AND CELL BIOLOGY PLATFORMS OF THE GUSTAVE ROUSSY COMPREHENSIVE CANCER CENTER

Guido Kroemer is currently Professor at the Faculty of Medicine of the University of Paris Descartes, Director of the research team "Apoptosis, Cancer and Immunity" of the French Medical Research Council (INSERM), Director of the Metabolomics and Cell Biology platforms of the Gustave Roussy Comprehensive Cancer Center, Deputy Director of the Cordeliers Research Center, and Hospital Practitioner at the Hôpital Européen George Pompidou, Paris, France. He is also a Foreign Adjunct Professor at the Karolinska Institute, Stockholm, Sweden.

 
Prior to joining INSERM (1994), Guido Kroemer was Senior Scientist of the European Community at the Spanish National Research Council (CSIC), at the National Center of Molecular Biology (1990-1992) and at the National Center of Biotechnology (1993). Guido Kroemer did his post-doctoral training in the Collège de France, Nogent-sur-Marne (1988-1989) and at the University of Innsbruck, Austria, after receiving his MD degree at the same University in 1985. He also holds a PhD degree in Molecular Biology (Autonomous University of Madrid, 1992).
 

FOCUS AREAS

Mitochondria and Cell Death. He is best known for the discovery that permeabilization of mitochondrial membranes constitutes a decisive step in programmed cell death. Kroemer has explored the fine mechanisms of mitochondrial cell death control, the molecular pathways that explain the inhibition of cell death in cancer cells, upstream of or at the level of mitochondria, and the mechanisms that make cancer cell death immunogenic.

His work has had far reaching implications for the comprehension, detection and therapeutic manipulation of cellular demise.

Awards and Honors

• Some of his honors include: The Lucien Dautrebande Prize of the Belgian Royal Academy of Medicine (2009), the Duquesne Prize of the French National League against Cancer (2010), and the Mitjavile Prize of the French Academy of Medicine (2014), the Galien Prize for Pharmacological Resarch (2015), the Grand Prix Claude Bernard of the City of Paris (2016), the Brupbacher Prize for Cancer Research (2017), the ADPS Longevity Research Award (2018) and the Baillet-Latour Health Prize (2018) among others.
  
  

aging critical publications

• López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. 2013 Jun 6;153(6):1194-217. 

• López-Otín C, Galluzzi L, Freije JM, Madeo F, Kroemer G. Metabolic control of longevity. Cell. 2016 Aug 11;166(4):802-21.

• Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, Harger A, Schipke J, Zimmermann A, Schmidt A, Tong M, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Magnes C, Trausinger G, Narath S, Meinitzer A, Hu Z, Kirsch A, Eller K, Carmona-Gutierrez D, Büttner S, Pietrocola F, Knittelfelder O, Schrepfer E, Rockenfeller P, Simonini C, Rahn A, Horsch M, Moreth K, Beckers J, Fuchs H, Gailus-Durner V, Neff F, Janik D, Rathkolb B, Rozman J, de Angelis MH, Moustafa T, Haemmerle G, Mayr M, Willeit P, von Frieling-Salewsky M, Pieske B, Scorrano L, Pieber T, Pechlaner R, Willeit J, Sigrist SJ, Linke WA, Mühlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G,* Sedej S, Madeo F. (*Corresponding author). Cardioprotection and lifespan extension by the natural polyamine spermidine. Nat Med. 2016 Dec;22(12):1428-1438.

• Madeo F, Eisenberg T, Pietrocola F, Kroemer. Spermidine in health and disease. Science. 2018 Jan 26;359(6374): 410. 

• Kroemer G, López-Otín C, Madeo F, de Cabo R. Carbotoxicity-Noxious effects of carbohydrates. Cell. 2018 Oct 18;175(3):605-614